Do calves need an IBR vaccine?

Turning calves out to grass for the first time is seriously rewarding. Rearing healthy calves in the first place takes great effort and hard work.

Minimising the impact of diseases like diarrhea and pneumonia can be challenging and this year was no exception. Weaning dairy calves, dealing with coccidiosis threats, pneumonia and clostridial vaccination; the calf ‘to do’ list can be comprehensive. What about IBR vaccination?

IBR – Infectious Bovine Rhinotracheitis

Infection with IBR virus is widespread in the cattle population in Ireland, with evidence of exposure in over 70% of herds (both beef and dairy).  It is capable of causing disease (both clinical and subclinical) resulting in huge economic losses at farm level through lack of production and treatment costs.

The majority of infections are seen in cattle greater than six months of age, however all ages are at risk of IBR.

Clinical infections usually occur when animals are infected for the first time. Signs such as discharge from the eyes and nose, loud laboured breathing, high temperatures, resulting depression and reduced appetite may be experienced. Milk yield may be affected, and abortion may also occur.

Subclinical infections are those without overt clinical signs and for this reason may go unnoticed for some time in a herd. Subclinical IBR can result in losses of 2.6kg of milk/cow/day.

Those infected for the first time shed high levels of the virus for approximately two weeks. At times of stress (e.g. mixing/housing/breeding/calving) the virus can reactivate, and that animal may shed again. Every time an animal sheds the virus it has the potential to infect more herd mates.

Control of IBR

There are 3 components to controlling this endemic disease:

  1. Vaccination
  2. Biosecurity
  3. Culling

Vaccination

For effective control of IBR, vaccination must:

  • Reduce the number of new infections – Main cause of virus spreading in a herd
  • Reduce severity of clinical signs – Limit cost of disease impact

The time to start vaccination depends on the particular epidemiological situation of each farm. In the absence of virus circulation among the young calf group, vaccination is started at the age of three months, revaccination six months later and all subsequent revaccinations within six to 12 month periods.

This will provide protection against IBR virus and minimise the number of animals that become carriers. Herds that have a moderate to high seroprevalence of IBR, are high-risk and/or have clinical signs are best to remain on a six monthly vaccination programme until IBR is under better control in the herd.

If vaccination needs to be carried out before the age of three months (high prevalence/high-risk herds/disease in calves) then intranasal vaccination is the recommended route in order to overcome maternally derived antibodies.

An intramuscular vaccination programme then commences at three-four months of age, as stated above. For the spring calving herd this will mean calves will receive their first dose of a live IBR vaccine in June/July 2021.

Bovilis IBR Marker live

Bovilis IBR marker live provides protection by reducing clinical signs and virus excretion. It is the only single dose IBR marker vaccine for use either intranasally or intramuscularly. It is a 2ml dose with a fast onset of immunity (four days after intranasal administration and 14 days after intramuscular administration).

Biosecurity

Biosecurity can be further divided into bio exclusion and bio-containment.

Bio exclusion (the process of keeping disease out of a herd) is of particular importance in Ireland as many herds purchase cattle (e.g. the stock bull), avail of contract rearing for heifers, attend marts or shows (present Covid-19 restrictions excluded).

IBR can cross distances of up to five metres so neighbouring cattle during the grazing season can also be a source of infection, or vice versa.

Bio containment (the process of reducing the threat of infection within a herd) relies mainly on herd management strategies such as segregating age groups and indeed vaccination.

Culling

Culling of animals which have tested positive for IBR is a quick method to reduce herd prevalence. However, in many herds it is not a practical option as there are simply too many animals which are positive (once infected an animal becomes a life-long carrier) and therefore it would not be economically viable.

In summary, the majority of herds in Ireland are of medium or high seroprevalence so vaccination with a live IBR marker vaccine combined with biosecurity are the most practical and appropriate control methods. Many herds are missing a trick by only vaccinating the cows.

This is controlling clinical signs and the impact of IBR on production but not necessarily reducing the spread (to unvaccinated younger cattle) and therefore the number of new infections each year.

The aim of whole herd vaccination is to reduce the level of IBR in the herd over time. In answer to the opening question – yes; to IBR vaccination of calves.


FAQ on IBR Control

Vaccination Starts With The Calf

There are 3 components to controlling this disease
1. Biosecurity
2. Culling
3. Vaccination

Biosecurity:
To keep the disease out of IBR free herds and to limit the spread in herds with IBR positive animals

Culling:
Culling of animals which have tested positive for IBR. In many herds it is not a practical option as there are simply too many animals which are positive (once infected an animal becomes a life-long carrier) and therefore it would not be economically viable.

IBR calf vaccination
Calves from 3 months of age can be vaccinated using Bovilis IBR Marker Live into the muscle

Vaccination
For effective control of IBR, vaccination must:
• Reduce the number of new infections – main cause of virus spreading in a herd
• Reduce severity of clinical signs – Limit cost of disease impact

FAQ on IBR disease and Bovilis IBR Marker Live


Do I need to vaccinate my herd for IBR?

75% of herds have been exposed to IBR, it is an endemic disease in Ireland. Clinical signs are not always present in infected cattle. Subclinical disease (without signs) can result in losses of 2.6kg of milk/cow/day. Speak to your vet regarding screening for the virus through bulk milk tank testing and blood sampling animals in your herd.

Herd level prevalence of IBR by county in Ireland1

I vaccinate my cows and heifers against IBR – should I vaccinate my calves?

The benefit from whole herd IBR vaccination starting with the youngstock is that the calves are protected from the virus and this minimises the number of animals that become carriers. Every animal that is infected with IBR becomes a lifelong (latent) carrier and these animals are the source of infection in the herd.

I vaccinate every 6 months against IBR – can I move to every 12 months now?

12 monthly vaccination (after the initial 2 vaccinations 6 months apart) may be suitable for low prevalence IBR herds. Speak to your vet on how to assess and monitor herd prevalence. Check out the below video showing how to get your herd onto the 12 month vaccination protocol for Bovilis IBR Marker Live. Again, consult with your vet to determine if your herd is suitable to move to the 12 month protocol

I got a high IBR reading in my bulk tank – what should I do?

Talk to your vet about what this high reading may mean in terms of virus in your herd. A high reading indicates that virus is actively circulating in the milking cow herd.

My bulk milk tank test is negative for IBR – does this mean my herd is IBR free?

Not necessarily; bulk tank antibody tests only detect IBR virus when at least 20% of the milking cows are carriers. If you have a suspicion that IBR is in your herd, speak to your vet regarding blood sampling individual animals.

I know IBR is circulating within my cow herd, can they pass the virus to the calves?

In short, yes they can. Cows are most likely to shed virus at times of stress e.g calving time, peak lactation. If calves are in the same air space (remember IBR can travel for 5 metres) as older animals who are shedding virus then they are vulnerable to the disease.

Sub-clinical IBR can have a significant impact on production output

My neighbouring farmer vaccinates for IBR – I’m a beef farmer, how do I check if my herd has IBR?

Blood sampling is the most common method to determine the prevalence of IBR disease within a beef herd. This involves sampling all animals or a representative number of animals in the herd. Talk to your vet for more information.

There is an outbreak of IBR on my farm – is it safe to use Bovilis IBR Marker Live in the face of an outbreak?

Yes, for the fastest onset of activity; 4 days, it can be given intranasally. Onset of immunity after intramuscular administration is 14 days.

I vaccinated my calves up the nose at 1 month of age against IBR – do I give them a booster?

Yes. Calves that received an initial shot of Bovilis IBR Marker Live up the nose will require a booster 2 ml shot, at 3-4 months of age. At this age or older animals, can be vaccinated either intranasally or into the muscle.

What is a marker vaccine?

Marker vaccines do not contain glycoprotein E (gE) and therefore do not cause production of antibodies to gE. Field virus and non-marker vaccines on the other hand do contain gE and therefore lead to production of antibodies to gE. An IBR gE ELISA test in herds that are vaccinating with marker vaccines allows differentiation between vaccine and wild virus antibodies. Non-marker vaccines are still available in Northern Ireland. IBR marker vaccines are the only type of IBR vaccine available in the Republic of Ireland.

Bovilis IBR Marker Live is the number 1 IBR vaccine in Ireland

Which vaccine should I use for IBR protection – live or inactivated?

Less shedding of the virus occurs in animals that have been vaccinated with a live vaccine compared to animals that had received inactivated vaccines. Studies have shown that live IBR marker vaccines provide better protection against clinical signs than inactivated vaccines. There is limited evidence that using inactivated vaccine can result in a better reduction of shedding by reactivated latently infected animals than live vaccine. Bulls intended for use as future AI sires must not be vaccinated with any type of IBR vaccine.

Addition info

Live vaccineInactivated vaccine
Primary courseStandard or low-risk herds
Young calves (2weeks-3months of age)Pedigree herds (except potential AI sires)
All herds including high-risk herds 
High prevalence herds 
In the face of an outbreak 
Comparison of live and inactivated IBR vaccines

Risk factors to a herd:

  • Purchasing stock (especially without a quarantine procedure)
  • Mixing stock from two different farms, including contract rearing operations
  • Poor boundary fences, IBR can spread for up to five metres
  • Bringing cattle to and from the mart
  • Attending agricultural shows
  • Personnel -Farm workers who are in contact with other stock

Talk to your vet today about IBR calf vaccination from 3 months of age, using Bovilis IBR Marker LiveFor more check out our brochure here, our IBR page or Twitter page


References
1. Bosch et al (1996) An attenuated bovine herpesvirus 1 vaccine induces better protection than two inactivated marker vaccines. Veterinary Microbiology 52, 223-234


Do calves need an IBR vaccine?


Turning calves out to grass for the first time is seriously rewarding. Rearing healthy calves in the first place takes great effort and hard work. Minimising the impact of diseases like diarrhoea and pneumonia can be challenging and this year was no exception with the storms of early spring to the warm daily temperatures and cold nights of April. Weaning dairy calves, dealing with coccidiosis threats, pneumonia and clostridial vaccination; the calf ‘to do’ list can be comprehensive. What about IBR calf vaccination?

3 month old calves can receive a 2 ml shot of Bovilis IBR Marker now followed by a 2 ml shot in 6 months time. They can then be vaccinated every 12 months

IBR – Infectious bovine rhinotracheitis

Infection with IBR virus is widespread in the cattle population in Ireland, with evidence of exposure in over 75% of herds (both beef and dairy).  It is capable of causing disease (both clinical and subclinical) resulting in huge economic losses at farm level through lack of production and treatment costs. The majority of infections are seen in cattle greater than 12 months of age. However all ages are at risk of IBR.

IBR Calf Vaccination
Herd level prevalence of IBR by county in Ireland1

Clinical infections usually occur when animals are infected for the first time. Signs such as discharge from the eyes and nose, loud laboured breathing, high temperatures, resulting depression and reduced appetite may be experienced. Milk yield may be affected, and abortion may also occur. Subclinical infections are those without overt clinical signs and for this reason may go unnoticed for some time in a herd. Subclinical IBR can result in losses of 2.6kg of milk/cow/day.

The financial impact of subclinical IBR can be significant

Those infected for the first time shed high levels of the virus for approximately two weeks. At times of stress (e.g. mixing/housing/breeding/calving) the virus can reactivate, and that animal may shed again. Every time an animal sheds the virus it has the potential to infect more herd mates.

Control of IBR

There are three components to controlling this endemic disease;

  1. Biosecurity
  2. Culling
  3. Vaccination

Biosecurity

Biosecurity can be further divided into two parts. Bio exclusion and bio containment.

Bio exclusion (the process of keeping disease out of a herd) is of particular importance in Ireland as many herds purchase cattle (e.g. the stock bull), avail of contract rearing for heifers, attend marts or shows (present Covid-19 times excluded). IBR can cross distances of up to five metres so neighbouring cattle during the grazing season can also be a source of infection or vice versa.

Bio containment (the process of reducing the threat of infection within a herd) relies mainly on herd management – segregating of age groups for example.

Culling

Culling of animals which have tested positive for IBR is a quick method to reduce herd prevalence. However, in many herds it is not a practical option as there are simply too many animals which are positive. Remember, once infected an animal becomes a life-long carrier and therefore it would not be economically viable option.

IBR Calf Vaccination
Bovilis IBR Marker Live is the No.1 IBR vaccine on the market in Ireland!

Vaccination

For effective control of IBR, vaccination must:

  • Reduce the number of new infections – Main cause of virus spreading in a herd
  • Reduce severity of clinical signs – Limit cost of disease impact

The time to start vaccination depends on the particular situation of each farm. In the absence of virus circulation among the young calf group, vaccination is started at the age of 3 months and revaccination 6 months later. All subsequent revaccinations within 12 month periods. This will provide protection against IBR virus and minimise the number of animals that become carriers. Herds that have a moderate to high prevalence of IBR, are high-risk and/or have clinical signs are best to remain on a six monthly vaccination programme until IBR is under better control in the herd. For the spring calving herd this will mean calves will receive their first dose of a live IBR vaccine in June/July 2020.

In high prevalence herds or where there is disease in the calves, vaccination will be needed sooner than 3 months. Intranasal IBR vaccination is the recommended route in order to overcome maternally derived antibodies in this scenario. An intramuscular vaccination programme then commences at three-four months of age as stated above. See video below explaining the vaccination protocol for Bovilis IBR Marker Live

Bovilis IBR Marker Live – 12 month vaccination protocol starts by vaccinating the calf from 3 months of age

Bovilis IBR marker live provides protection by reducing clinical signs and virus excretion. It is the only single dose IBR marker vaccine for use either intranasally or intramuscularly. It is a 2ml dose with the fastest onset of immunity (four days after intranasal administration and 14 days after intramuscular administration).

The majority of herds in Ireland are of medium or high seroprevalence. Vaccination with a live IBR marker vaccine combined with biosecurity and monitoring are the most practical and appropriate control methods. Many herds are missing a trick by only vaccinating the cows. This is controlling clinical signs and the impact of IBR on production but not necessarily reducing the spread (to unvaccinated younger cattle) and therefore the number of new infections each year. The aim of whole herd vaccination is to reduce the level of IBR in the herd over time. In answer to the opening question – yes; to IBR vaccination of calves.

Talk to your vet today about IBR calf vaccination from 3 months of age, using Bovilis IBR Marker Live. For more check out our brochure here, our IBR page or Twitter page

References
1. Bosch et al (1996) An attenuated bovine herpesvirus 1 vaccine induces better protection than two inactivated marker vaccines. Veterinary Microbiology 52, 223-234