IBR Product Image

(IBR) Infectious Bovine Rhinotracheitis

IBR stands for Infectious Bovine Rhinotracheitis. As the name suggests it is an infectious respiratory disease of cattle.

Bovilis IBR Marker Live – How to get your herd onto the 12-month vaccination protocol

New Thinking On IBR Control – Calf Vaccination

There are many benefits to beginning IBR calf vaccination early in life. Research has shown that in the first two months of life, dairy calves that are successfully treated for a single case of Bovine Respiratory Disease (BRD) produce 4% less milk in their first lactation and 8% less in their second lactation. Both clinical and subclinical disease can cause a reduction in daily live weight gain in both beef and dairy calves. Therefore reducing the incidence of bovine respiratory disease makes economic sense.

2022 spring born calves that are 3 months of age or older can receive a 2ml shot into the muscle. These calves then receive their booster shot 6 months later. An annual booster shot can then be administered to these cattle every 12 months using Bovilis® IBR Marker Live thereafter. Farmers should talk to their veterinary practitioner for advice on the best IBR vaccination programme for their herd.

When should I start vaccinating against IBR?

The time to start vaccinating against IBR depends on the particular situation of each herd. MSD Animal Health propose taking the whole herd approach to protecting cattle against IBR by starting with the young stock. Calves from 3 months of age receive a 2 ml shot of Bovilis® IBR Marker Live into the muscle. In herds where IBR is widespread, a 2 ml shot can be administered up the nose from 2 weeks of age. 1 ml in either nostril.

IBR calf vaccination
Calves from 3 months of age can receive a 2ml shot of Bovilis IBR Marker Live into the muscle


What causes IBR?

IBR is caused by a virus called Bovine Herpes Virus-1(BHV-1). BHV-1 is unique in that after cattle become infected they become carriers of the disease. The virus can lie latent – or hidden in the animal’s body. It is not possible to tell from looking at the animal if they are a carrier. You need to do a blood test to establish if the animal is a carrier. The disease can reactivate at times of stress. When it reactivates the animal sheds the virus which can result in other animals becoming infected.

What are the signs of IBR?

The clinical signs associated with the disease are fever and respiratory signs such as runny nose, discharge from the eyes and coughing. IBR in dairy herds is associated with a drop in milk yield. It can also cause abortion.

How can you diagnose IBR?

If your herd is experiencing some of the clinical signs described above and you suspect IBR is causing a problem in your herd talk to your vet. Nasal swabs can be used to identify cattle that are shedding virus and bloods can be used to identify latently infected animals.

How is IBR spread?

Direct nose to nose contact is the main cause of spreading within herds. It can also be spread via mucus or via aerosol, in the air breathed or sneezed out.  Airborne spread can occur over distances of up to 5 meters. IBR can be transferred by people, objects and farm utensils and can also be spread by semen from infected bulls.

When latently infected or carrier animals become stressed they shed enough virus to infect naïve (uninfected) animals. These newly infected animals shed much larger quantities of virus and spread it to other naïve animals. It is this spread from recently infected to naïve animal that is responsible for the main spread of virus in an outbreak and spread of disease throughout a naïve herd. The latently infected animals really just act as a reservoir for virus. A newly infected animal can infect up to 6 to 7 naïve in-contact animals, so you can see how easily the virus can spread though the herd when the animals are in close contact.

Subclinical IBR can result in losses of 2.6kg milk per cow per day

How can I treat IBR?

Once animals are latently infected or carriers they remain carriers for life. You can treat the animals individually as they show clinical signs but to control the disease and its impact on herd production you need to vaccinate.

Vaccine protocol for Bovilis IBR Marker live

The old licence claim stated that after the primary course of Bovilis® IBR Marker Live was administered, booster vaccines had to be administered every 6 months thereafter to maintain duration of immunity. The new licence claim states that after the initial injection of Bovilis® IBR Marker Live is administered, a second re-vaccination must be administered 6 months later, booster vaccines can then be administered no greater than every 12 months to maintain duration of immunity  Figure 2 below clearly highlights the new Bovilis® IBR

Which vaccine should I use – live or inactivated?

There are two types of IBR vaccines, live vaccines and inactivated vaccines. Vaccinating with the live vaccine results in less shedding of BHV-1 (IBR) virus in newly infected naïve animals than the inactivated vaccine ˡ. There is also limited evidence that using inactivated vaccine can result in a better reduction of shedding by reactivated latently infected animals than live vaccine³. However, a number of studies have showed that live IBR marker vaccines provide better protection against clinical signs than inactivated vaccinesˡ ². Speak to your vet for more information on the advantages of live IBR marker vaccines and which vaccination regime is most suited to your herd circumstances.

Keep an eye on our Twitter page for more information. Bovilis IBR Marker Live can be administer on the same day as Bovipast RSP from 3 weeks of age. More information here

(1) An attenuated bovine herpesvirus 1 vaccine induces better protection than two inactivated marker vaccines, Bosch et al, Veterinary Microbiology 52 (1996) 223-234

(2) H. Kuijk TIERÄRZTLICHE UMSCHAU (2004) 59, 3, p 168 – 172

(3) Bosch, J. C., Kaashoek, M. J., & Van Oirschot, J. T. (1997). Inactivated bovine herpesvirus 1 marker vaccines are more efficacious in reducing virus excretion after reactivation than a live marker vaccine. Vaccine, 15(14), 1512-1517.